"When Isaac’s mother starts hearing the voice of God demanding a sacrifice be made to prove her faith, Isaac escapes into the basement, where he faces droves of deranged enemies, lost brothers and sisters, his fears and eventually his mother. Gameplay The Binding of Isaac: Rebirth is the randomly generated action RPG shooter that started the new roguelike era. Following Isaac on his journey, players will find bizarre treasures that change Isaac’s form, giving him superhuman abilities and enabli